Hypoglycemic effects of Salvia officinalis L. Stem Extract in Dexamethasone-Induced Albino Rats

Abstract

The sage plant (Salvia Officinalis L.) has been reported in previous studies to exhibit hypoglycemic properties. The researcher evaluates the effectiveness of sage plant stem extract in lowering blood sugar level in albino rats induced with dexamethasone, examining numerous dosages and considering its efficacy as a remedy for type II diabetes, using metformin as positive control.  The results indicated that sage plant stem extract substantially reduced blood glucose level in dexamethasone-induced albino rats, especially at a 50% dosage, showing constant decreases in each blood sugar levels and heart rates. No observable difference in glucose-lowering trend was noted between 50% stem extract group and metformin-treated rat. However, the 25% concentration did not drastically have an effect on blood sugar levels compared to other doses. Some potential side effects, such as reduced appetite, were observed. These findings recommend that sage plant stem extract ought to offer a promising alternative remedy for type II diabetes, leading to the approval of new medication and the development of pharmaceutical merchandise based on herbal treatments. In conclusion, the studies support the hypoglycemic efficacy of sage plant stem extract, in particular at a 50% dosage. Further therapeutic potential of other parts of Salvia officinalis, including other hematological analysis related to blood sugar increase, like ketone and lipoproteins analysis, is recommended.